Menopoz durumunun moleküler meme kanseri alt tipleri ile ilişkisi.

Objective
 Breast cancer is a heterogeneous disease group that exhibits quite different biological behaviors and bear many genomic traces. Its dependence on sex hormones also determines its relationship with menopausal status. It divided into five molecular subtypes according to receptor analysis Ki67 level immunohistochemical (IHC) markers. This study aimed examine the between status these help determine our treatment strategies.
 Material Method
 The database of 250 patients who were operated for breast in Oncology Clinic 2012 2020 was retrospectively analyzed. grouped by their clinicopathological characteristics. Statistical made at 95% confidence interval, p-value lower than 0.05 considered statistically significant.
 Results 
 2 groups as 44.8% (n = 112) premenopausal 65.2% (n=138) postmenopausal. In statistical performed, high women (p=0.015). Also, tumors seen associated ER negativity (p=0.024) histological grade (grade3) found luminal subtype (luminal A, B) cancers observed more frequently postmenopausal non-luminal (HER2+, TNBC) women.
 Conclusion
 complexity will personalized strategies soon remains be clarified. There still need randomized, prospective, multidisciplinary, population-based studies us understand this unknown nature.